im all up for this idea,but lets try keep it simple if we are going to talk about this :P
so lets say universe generates one civilization on some random distant planet..
first it generates buildings,with min/max number of NPC-s ...
(there should be 3 stages of civilizations:
-primitive: wild NPC-s with wooden houses
-middle ages: Stone keeps and castles,stone fortesses
-and modern/space age: normal city,and space shipss)
and each of those civs will react to your actions as the current pirates/Guild react
what im looking forward,is invading those planets with my mighty SkyCorp warships,exterminating local population,and enslaving all who resist >:D mwhahhah