If you mean a player shop, then yes. would love to raid player shops lol.
If you mean Trade Guild shops, I am not sure how that would work into the economy. Maybe as ToyotaSupra said you could be branded a pirate. Then the trade guild would send MANY more ships after you. Or just much larger ships. Or better yet a mixed fleet with a few battleships and some fighters mixed in. Though they should likely not carry loot to you at that point. they would be pretty retarded to carry a bunch of "restock" cargo on an assault mission....